PERAN INTERLEUKIN-6 SELAMA INFEKSI VIRUS

This latter finding supports the hypothesis that upregulation of IL-6 during certain viral infections may increase survival and/or clinical disease exacerbation. The number genes regulated by activity explain pleotropic properties these interleukins. Thus, biological consequences production have been associated with pro and anti-inflammatory effects (Scheller et al., 2011), highlighting important role in activation regulation immune responses. Biological activities affected include: controlling monocyte differentiation into macrophages regulating expression macrophage colony-stimulating factors (Chomarat 2000), increasing B cell IgG IL-21 (Yang 2016). ), negative dendritic maturation STAT3 signaling pathway (Park 2004), as well promotion Th2 responses inhibiting Th1 polarization (Diehl Rincon, 2002). Moreover, combination growth-altering beta factor, induces naive CD4 Th17 cells, which are essential for defense against pathogens at mucosal sites (Guglani Khader, 2010). Also, synergistic interaction IL-7 IL-15 cytolytic capacity CD8 T cells (Cox 2013). Importantly, is a potent pyrogenic cytokine, has an lymphocyte trafficking to lymphoid organs febrile events (Evans 2015).